The wind chill factor is expected to drop between 25 and 35 below zero Tuesday night until Wednesday morning.
The National Weather Service in Duluth issued an advisory for Northeastern Minnesota, including St. Louis, Carlton, Cook and Lake counties.
In Douglas County, the wind chill is predicted to be 20 degrees below zero.
The wind chill is expected to be the coldest between midnight and 9 a.m. Wednesday. Exposed skin can develop frostbite in 15-30 minutes at the forecast wind chill.
Lake effect snow will affect portions of the southern shore of Lake Superior. A winter weather advisory in Iron County is in effect until Wednesday morning.
The weather service is also predicting snowfall in northern Minnesota Wednesday night into Thursday, with the possibility of freezing drizzle. There is still some uncertainty in how much snow will fall across northern Minnesota Wednesday night and Thursday.
Currently, the weather service is predicting 1-2 inches in Duluth and Superior, 4-6 inches in Silver Bay, 3-4 inches in Ely and 6-8 inches in Grand Marais.